2. Immunology/Inflammation
  3. COX
  4. Propyphenazone

Propyphenazone  (Synonyms: 4-Isopropylantipyrine; Isopropylphenazone)

Cat. No.: HY-A0273 Purity: 99.94%
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Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity.

For research use only. We do not sell to patients.

Propyphenazone Chemical Structure

Propyphenazone Chemical Structure

CAS No. : 479-92-5

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Other Forms of Propyphenazone:

Propyphenazone Related Antibodies

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Description

Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity[1][2].

IC50 & Target[1]

COX

 

In Vivo

Propyphenazone (4-Isopropylantipyrine; 0.7, 7, 70 mg/kg; oral gavage; the entire second week of gestation, days 8-14 of gestation), administered Propyphenazone:Caffeine and Propyphenazone:Paracetamol mixtures with constant 3:1 and 3:5 ratios, causes intrauterine growth retardation but does not increase external or internal congenital anomalies in pregnant Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

230.31

Formula

C14H18N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 2.6 mg/mL (11.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3420 mL 21.7099 mL 43.4197 mL
5 mM 0.8684 mL 4.3420 mL 8.6839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3420 mL 21.7099 mL 43.4197 mL 108.5493 mL
5 mM 0.8684 mL 4.3420 mL 8.6839 mL 21.7099 mL
10 mM 0.4342 mL 2.1710 mL 4.3420 mL 10.8549 mL
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Propyphenazone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propyphenazone479-92-54-Isopropylantipyrine IsopropylphenazoneCOXCyclooxygenasePyrazolenonsteroidal anti-inflammatory drugNSAIDreducing painanti-inflammatoryanalgesicInhibitorinhibitorinhibit

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