2. Signaling Pathways
  3. GPCR/G Protein
  4. GPR84
  5. GPR84 Agonist

GPR84 Agonist

GPR84 Agonists (6):

Cat. No. Product Name Effect Purity
  • HY-12764
    6-OAU
    		Agonist 99.91%
    6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function.
  • HY-124571
    ZQ-16
    		Agonist 99.88%
    ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120.
  • HY-163350
    TUG-2208
    		Agonist
    TUG-2208 (compound 42a) is a GPR84 agonist with low lipophilicity and good solubility, in vitro permeability and microsomal stability.
  • HY-161106
    OX04528
    		Agonist
    OX04528 (compound 68) is a potent, G-protein biased, and orally active GPR84 agonist. OX04528 no cytotoxicity. OX04528 inhibits cAMP production with an EC50 value of 0.00598 nM.
  • HY-126346
    DL-175
    		Agonist
    DL-175 (compound 13) is a selective GPR84 agonist with biased agonistic activity. DL-175 can selectively activate functional responses in immune cells and induce enhanced chemotaxis and phagocytosis of human bone marrow cells. DL-175 is a potential chemical probe.
  • HY-161107
    OX04529
    		Agonist
    OX04529 (compound 69) is a potent, selective and orally active agonist of GPR84. OX04529 inhibits FSK-induced cAMP production with an EC50 of 0.0185 nM. OX04529 displayed excellent potency, high G-protein signaling bias.