2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    NF-κB
  4. MALT1

MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

MALT1

Related Products

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MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.

MALT1 Related Products (27):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143423A
    (S)-MALT1-IN-5
    		Inhibitor
    (S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1).
    (S)-MALT1-IN-5
  • HY-P4544
    Val-Arg-Pro-DL-Arg-Fluoromethylketone
    		Inhibitor
    Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity.
    Val-Arg-Pro-DL-Arg-Fluoromethylketone
  • HY-143426
    MALT1-IN-8
    		Inhibitor
    MALT1-IN-8 is a potent MALT1 protease inhibitor with a IC50 of 2 nM. MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells with an IC50 of 1.16 μM. MALT1-IN-8 has anticancer effects (WO2018165385A1; Compound 8).
    MALT1-IN-8
  • HY-143422A
    (R)-MALT1-IN-3
    		Inhibitor
    (R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC50 of 20 nM. (R)-MALT1-IN-3 has IC50 of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively.
    (R)-MALT1-IN-3
  • HY-143424
    MALT1-IN-6
    		Inhibitor
    MALT1-IN-6 is a potent MALT1 protease inhibitor with a Ki of 9 nM. MALT1-IN-6 has anticancer effects (WO2018226150A1; Compound 4).
    MALT1-IN-6
  • HY-151805
    RGT-068A
    		Inhibitor
    RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor.
    RGT-068A
  • HY-143425
    MALT1-IN-7
    		Inhibitor
    MALT1-IN-7 (compound 142b) is a potent MALT1 protease inhibitor. MALT1-IN-7 has the potential for cancer research.
    MALT1-IN-7