MEK Inhibitors

MEK1

MEK2

MEK5

MEK

MEK Inhibitors, Antagonists & Activators

Product Name	MEK1	MEK2	MEK5	MEK	Purity
Trametinib	MEK1, IC₅₀: 2 nM	MEK2, IC₅₀: 2 nM			99.47%
PD98059	MEK1, IC₅₀: 2-7 μM	MEK2, IC₅₀: 50 μM			99.96%
Mirdametinib	MEK1, Ki: 1 nM	MEK2, Ki: 1 nM		MEK, IC₅₀: 0.33 nM	99.95%
U0126-EtOH	MEK1, IC₅₀: 70 nM	MEK2, IC₅₀: 60 nM			99.41%
Selumetinib	MEK1, IC₅₀: 14 nM			MEK, IC₅₀: 12 nM	99.87%
Cobimetinib	MEK1, IC₅₀: 4.2 nM				99.73%
Binimetinib				MEK, IC₅₀: 12 nM	99.50%
U0126	MEK1, IC₅₀: 70 nM	MEK2, IC₅₀: 60 nM			98.45%
C16-PAF				MEK	99.48%
Isorhamnetin	MEK1				99.95%
Trametinib (DMSO solvate)	MEK1, IC₅₀: 2 nM	MEK2, IC₅₀: 2 nM			99.74%
Avutometinib				MEK, IC₅₀: 160 nM	98.99%
Lidocaine				MEK	99.96%
Pimasertib	MEK1	MEK2			99.88%
CI-1040	MEK1, IC₅₀: 17 nM				99.86%
BIX02189			MEK5, IC₅₀: 1.5 nM		99.99%
trans-Zeatin				MEK	99.83%
GDC-0623	MEK1, Ki: 0.13 nM (+ATP)				99.15%
Lidocaine hydrochloride				MEK	99.96%
TAK-733				MEK, IC₅₀: 3.2 nM	98.31%
Refametinib	MEK1, IC₅₀: 19 nM	MEK2, IC₅₀: 47 nM			99.82%
MS432	MEK1, DC₅₀: 31 nM (in HT29 cells) MEK1, DC₅₀: 31 nM (in SK-MEL-28 cells)	MEK2, DC₅₀: 17 nM (in HT29 cells) MEK2, DC₅₀: 9.3 nM (in SK-MEL-28 cells)			99.78%
BI-847325		MEK2, IC₅₀: 4 nM			98.66%
APS-2-79	MEK1				99.48%
AZD8330	MEK1, IC₅₀: 7 nM	MEK2, IC₅₀: 7 nM			99.14%
Trametiglue	MEK1	MEK2			98.58%
SL327	MEK1, IC₅₀: 180 nM	MEK2, IC₅₀: 220 nM			≥98.0%
RGB-286638	MEK1, IC₅₀: 54 nM				99.84%
Lixisenatide	MEK1	MEK2			99.93%
RO4987655	MEK1, IC₅₀: 5.2 nM	MEK2, IC₅₀: 5.2 nM			99.26%
GW284543			MEK5		99.99%
MAP855	MEK1, IC₅₀: 3 nM				99.38%
PD318088	MEK1	MEK2			99.91%
Zapnometinib				MEK, IC₅₀: 5.7 nM	99.63%
BIX02188			MEK5, IC₅₀: 4.3 nM		99.85%
Cobimetinib hemifumarate	MEK1, IC₅₀: 4.2 nM				99.73%
MEK inhibitor				MEK	98.35%
Lidocaine (Standard)				MEK	99.85%
PD184161				MEK, IC₅₀: 10-100 nM	99.38%
PD0325901-O-C2-dioxolane	MEK1	MEK2			98.76%
Hypothemycin	MEK1, Ki: 17 nM	MEK2, Ki: 38 nM			≥98.0%
RGB-286638 free base	MEK1, IC₅₀: 54 nM				98.07%
Refametinib (R enantiomer)				MEK, EC₅₀: 2-15 nM
PD 198306				MEK
E6201	MEK1, IC₅₀: 5.2 nM
PD-334581	MEK1
Balamapimod				MEK
GW284543 hydrochloride			MEK5
MEK-IN-6				MEK	98.69%
MEK/PI3K-IN-2	MEK1, IC₅₀: 352 ± 2 nM
MEK/PI3K-IN-1	MEK1, IC₅₀: 124 ± 11 nM
Isorhamnetin (Standard)	MEK1
Lidocaine hydrochloride hydrate				MEK
CHMFL-EGFR-202	MEK1, IC₅₀: 161 nM				99.75%
MEK-IN-6 hydrate				MEK
MEK-IN-1				MEK

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