2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PGC-1α

PGC-1α

PPARγ coactivator-1α

PGC-1α

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Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) serves as an inducible coregulator in the control of energy homeostasis. PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, including components of the electron transport system. PGC-1α is expressed abundantly in tissues with high energy demand, including brown adipose tissue, heart, skeletal muscle, kidney, and brain. PGC-1α has been shown to regulate adaptive thermogenesis, mitochondrial biogenesis, glucose and fatty acid metabolism, the peripheral circadian clock, fiber-type switching in skeletal muscle, and heart development. PGC-1α, a critical booster of mitochondrial function, is an excellent candidate for preventing insulin resistance and metabolic syndromes secondary to mitochondrial dysfunction. PGC-1α has been shown to influence energy metabolism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101491
    SR-18292
    		Inhibitor 99.82%
    SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
    SR-18292
  • HY-17538
    ZLN005
    		Activator 99.94%
    ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).
    ZLN005
  • HY-N0378
    D-Mannitol
    		Activator 99.93%
    D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
    D-Mannitol
  • HY-N7439
    Mogroside VI B
    		Activator 98.97%
    Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription.
    Mogroside VI B
  • HY-P5763
    Phoenixin-20
    		99.68%
    Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect.
    Phoenixin-20
  • HY-P5763A
    Phoenixin-20 TFA
    Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 (TFA) has anxiolytic effect.
    Phoenixin-20 TFA
  • HY-P5225
    Acetyl hexapeptide-38
    		Inducer
    Acetyl hexapeptide-38 is a bioactive peptide with upregulate adipogenesis effect and has been reported used as a cosmetic ingredient.
    Acetyl hexapeptide-38
  • HY-P3455
    Ac-SVVVRT-NH2
    		Modulator 98.50%
    Ac-SVVVRT-NH2 is a PGC-1α modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α.
    Ac-SVVVRT-NH2
  • HY-17538S
    ZLN005-d4
    		Activator 99.52%
    ZLN005-d4 is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].
    ZLN005-d<sub>4</sub>
  • HY-N12011
    11-Oxoisomogroside V
    		Activator
    11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81%.
    11-Oxoisomogroside V
Cat. No. Product Name / Synonyms Application Reactivity