ClpP

Caseinolytic protease P

Caseinolytic protease P (ClpP) is a mitochondrial serine protease. In mammalian cells, the heterodimerization of ClpP and its AAA+ ClpX chaperone results in a complex called ClpXP, which has a relevant role in protein homeostasis and in maintaining mitochondrial functionality through the degradation of mitochondrial misfolded or damaged proteins.

ClpP Related Products (8):

By Effects:	Inhibitors (5) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-111532

(3R,4R)-A2-32-01	Inhibitor	99.43%
(3R,4R)-A2-32-01 (compound 24(R,R)), the (R,R)-enantiomer of A2-32-01, is a Staphylococcus aureus caseinolytic protease (SaClpP) inhibitor.

HY-111532B

(3S,4S)-A2-32-01	Inhibitor	98.15%
(3S,4S)-A2-32-01 (compound 24(S,S)), a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor.

HY-152097

(S)-ZG197	Inhibitor
(S)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC₅₀ of 1.4 μM.

HY-152096

(R)-ZG197	Inhibitor
(R)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC₅₀ of 1.5 μM. (R)-ZG197 also activates Homo sapiens ClpP (HsClpP) with an EC₅₀ of 31.4 μM.

HY-163319

NCA029	Activator
NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC₅₀ of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death.

HY-155556

ZG36	Inhibitor
ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model.

HY-P4284

Z-GGF-CMK
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM.

HY-P4399

Z-Gly-Gly-Leu-AMC
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu.

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