2. Signaling Pathways
  3. Immunology/Inflammation
  4. Galectin
  5. Galectin Inhibitor

Galectin Inhibitor

Galectin Isoform Comparison

Galectin Inhibitors (17):

Cat. No. Product Name Effect Purity
  • HY-114409
    GB1107
    		Inhibitor 99.92%
    GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.
  • HY-147041
    Selvigaltin
    		Inhibitor 98.72%
    Selvigaltin (GB1211) is an orally available galectin-3 (Gal-3) inhibitor.
  • HY-130208
    Thiodigalactoside
    		Inhibitor 99.97%
    Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
  • HY-W150340
    β-Lactose
    		Inhibitor ≥98.0%
    β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.
  • HY-114440
    Belapectin
    		Inhibitor
    Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.
  • HY-157821
    Galectin-4-IN-3
    		Inhibitor
    Galectin-4-IN-3 (Compound 11) is a Galectin 4C inhibitor, with a Kd of 160 μM.
  • HY-157822
    Galectin-8-IN-2
    		Inhibitor
    Galectin-8-IN-2 (Compound 10) is a galectin-8N inhibitor.
  • HY-157824
    6Lac[6]Met
    		Inhibitor
    6Lac[6]Met is a galectin 4 inhibitor with an IC50 value 5 μM.
  • HY-150235
    Galectin-8N-IN-1
    		Inhibitor 98.09%
    Galectin-8N-IN-1 (compound 19a) is a potent and selective galectin-8N inhibitor with a Kd value of 1.8 μM. Galectin-8N-IN-1 is a galectin-8N ligand. Galectin-8N-IN-1 can be used in research of immune system.
  • HY-155192
    Galectin-3/galectin-8-IN-2
    		Inhibitor
    Galectin-3/galectin-8-IN-2 (Compound 57) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 12.8 μM and 2.06 μM respectively. Galectin-3/galectin-8-IN-2 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-2 can be used for research of cancer and tissue fibrosis.
  • HY-155191
    Galectin-3/galectin-8-IN-1
    		Inhibitor
    Galectin-3/galectin-8-IN-1 (Compound 53) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 4.12 μM and 6.04 μM respectively. Galectin-3/galectin-8-IN-1 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-1 can be used for research of cancer and tissue fibrosis.
  • HY-147865
    Apoptosis inducer 8
    		Inhibitor
    Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent.
  • HY-163407
    Galectin-3-IN-4
    		Inhibitor
    Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively.
  • HY-144313
    Galectin-3-IN-2
    		Inhibitor
    Galectin-3-IN-2 (Compound 9) is a potent multivalent inhibitor of galectin-3 (Gal-3; IC50=8.3 μM). Galectin-3 participates in many cancer-related metabolic processes.
  • HY-163405
    Galectin-3-IN-3
    		Inhibitor
    Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.
  • HY-144312
    Galectin-3-IN-1
    		Inhibitor 99.76%
    Galectin-3-IN-1 (Compound 1) is a potent multivalent inhibitor of galectin-3 (Gal-3). Galectin-3 participates in many cancer-related metabolic processes. Galectin-3-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-163082
    GB1490
    		Inhibitor
    GB1490 is an orally active galectin inhibitor with Kd values of 0.4 μM and 2.7 μM for galectin-1 and galectin-3, respectively.