2. Metabolic Enzyme/Protease Anti-infection Cell Cycle/DNA Damage Apoptosis Others Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. Mitochondrial Metabolism Parasite CDK MDM-2/p53 Others Caspase VEGFR Interleukin Related
  4. Thiabendazole

Thiabendazole  (Synonyms: Tiabendazole; 2-(4-Thiazolyl)benzimidazole)

Cat. No.: HY-B0263 Purity: 99.65%
COA Handling Instructions

Molarity Calculator

Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling.

For research use only. We do not sell to patients.

Thiabendazole Chemical Structure

Thiabendazole Chemical Structure

CAS No. : 148-79-8

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thiabendazole:

Thiabendazole Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Thiabendazole

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling[1][2][3][4][5].

IC50 & Target

CDK2

 

CCNE1

 

bax

 

Caspase-9

 

Caspase 3

 

IL-1β

 

IL-10

 

IL-6

 

IL-13

 

IFN-gamma

 

In Vitro

Thiabendazole (0/50/100/200/300/400/500 μM, 24/48/72 h) time- and dose-dependently inhibits B16F10 and B16 cells proliferation[2].
Thiabendazole (250 μM, 16 h) inhibits angiogenesis in Xenopus embryos and disrupts newly established vasculature[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiabendazole Related Antibodies

Cell Viability Assay[2]

Cell Line: B16F10, B16
Concentration: 0/50/100/200/300/400/500 μM
Incubation Time: 24/48/72 h
Result: Suggested that thiabendazole exhibited inhibitory effects to murine melanoma cell lines in vitro.
The IC50 values of B16 cells were 540.8, 410.7, 280.4 μM at 24, 48, and 72 h, respectively.
And the IC50 values of B16F10 cells were 532.4, 322.9, 238.5 μM at 24, 48, and 72 h, respectively.
In Vivo

Thiabendazole (50 mg/kg, 27 days) slows tumor growth in a mouse Xenopus model[3].
Thiabendazole (0/0.5/1/2/4/5/10/20/ mg/L, 0-96 hpf) induces developmental defects in zebrafish through apoptosis, oxidative stress, and changes of PI3K/Akt and MAPK pathwayssup>[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult male, 173±4 g average weight)[6]
Dosage: 90 mg/L, daily oral exposure for 90 days
Administration: p.o.
Result: Significantly changed the blood parameters in the sample.
(1) Significantly altered blood parameters in the samples.
(2) Red blood cells count and hemoglobin content were significantly reduced.
(3) Platelet count dropped significantly.
(4) The mean values of MCV (mean corpuscular volume) and MCH (mean corpuscular hemoglobin) were significantly increased.
(5) Eosinophil content was significantly reduced.
Significantly reduced the expression levels of immunoglobulins IgG and IgM.
Significantly up-regulated the inflammatory factors (TNF-α, INF-γ, IL-1β, IL-6, L-10 and IL-13) in spleen tissue.and the cytokines CD4 increased and CD8 decreased.
Animal Model: Wild-type zebrafish (AB strain) and transgenic zebrafish models, including flk1:eGFP, olig2:dsRed, and L-fabp:dsRed;elastase:GFP)[4]
Dosage: 0/0.5/1/2/4/5/10/20 mg/L
Administration: Soak drug administration
Result: None of the embryos exposed to 20 and 50 mg/L of thiamendam survived.
Induced apoptosis and cell cycle arrest in zebrafish larvae.
Reduced the expression levels of antioxidant enzymes inducing ROS production and inflammatory response.
Induced cardiovascular defects in zebrafish larvae.
Caused motor neuron toxicity in zebrafish larvae.
Caused hepatotoxicity and pancreatic toxicity.
Molecular Weight

201.25

Formula

C10H7N3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1(C2=CSC=N2)=NC3=CC=CC=C3N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (248.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9689 mL 24.8447 mL 49.6894 mL
5 mM 0.9938 mL 4.9689 mL 9.9379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.42 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (12.42 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.72%

COA (249 KB) HNMR (244 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9689 mL 24.8447 mL 49.6894 mL 124.2236 mL
5 mM 0.9938 mL 4.9689 mL 9.9379 mL 24.8447 mL
10 mM 0.4969 mL 2.4845 mL 4.9689 mL 12.4224 mL
15 mM 0.3313 mL 1.6563 mL 3.3126 mL 8.2816 mL
20 mM 0.2484 mL 1.2422 mL 2.4845 mL 6.2112 mL
25 mM 0.1988 mL 0.9938 mL 1.9876 mL 4.9689 mL
30 mM 0.1656 mL 0.8282 mL 1.6563 mL 4.1408 mL
40 mM 0.1242 mL 0.6211 mL 1.2422 mL 3.1056 mL
50 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4845 mL
60 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0704 mL
80 mM 0.0621 mL 0.3106 mL 0.6211 mL 1.5528 mL
100 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2422 mL
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Thiabendazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiabendazole148-79-8Tiabendazole 2-(4-Thiazolyl)benzimidazoleMitochondrial MetabolismParasiteCDKMDM-2/p53OthersCaspaseVEGFRInterleukin RelatedCyclin dependent kinaseVascular endothelial growth factor receptorILAnalytical methodsVEGFB16F10B16Cell viabilityRT-PCRApoptosisAnthelminticOrally activityOxidative stressPI3K/AktMAPKInhibitorinhibitorinhibit

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