2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. U93631

U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.

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U93631 Chemical Structure

U93631 Chemical Structure

CAS No. : 152273-12-6

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 55 In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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Description

U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. target: GABAA receptor IC 50: GABAA receptor[1] In vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization, rather than acting as an open channel blocker. [1]

Molecular Weight

299.37

Formula

C17H21N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2N(C=N1)C3=C(C=CC=C3)NC2(C)C)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (113.57 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3403 mL 16.7017 mL 33.4035 mL
5 mM 0.6681 mL 3.3403 mL 6.6807 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3403 mL 16.7017 mL 33.4035 mL 83.5087 mL
5 mM 0.6681 mL 3.3403 mL 6.6807 mL 16.7017 mL
10 mM 0.3340 mL 1.6702 mL 3.3403 mL 8.3509 mL
15 mM 0.2227 mL 1.1134 mL 2.2269 mL 5.5672 mL
20 mM 0.1670 mL 0.8351 mL 1.6702 mL 4.1754 mL
25 mM 0.1336 mL 0.6681 mL 1.3361 mL 3.3403 mL
30 mM 0.1113 mL 0.5567 mL 1.1134 mL 2.7836 mL
40 mM 0.0835 mL 0.4175 mL 0.8351 mL 2.0877 mL
50 mM 0.0668 mL 0.3340 mL 0.6681 mL 1.6702 mL
60 mM 0.0557 mL 0.2784 mL 0.5567 mL 1.3918 mL
80 mM 0.0418 mL 0.2088 mL 0.4175 mL 1.0439 mL
100 mM 0.0334 mL 0.1670 mL 0.3340 mL 0.8351 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U93631152273-12-6U 93631U-93631GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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