2. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin Drug-Linker Conjugates for ADC
  4. Vc-MMAD

Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD). Vc-MMAD is a agent-linker conjugate for ADC.

For research use only. We do not sell to patients.

Vc-MMAD Chemical Structure

Vc-MMAD Chemical Structure

CAS No. : 1401963-17-4

Size Price Stock Quantity
1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 880 In-stock
50 mg USD 1200 In-stock
100 mg USD 1600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Vc-MMAD Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD). Vc-MMAD is a agent-linker conjugate for ADC.

IC50 & Target

Auristatin

 

Molecular Weight

1369.71

Formula

C70H104N12O14S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC(N([C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N3[C@@H](CCC3)[C@H](OC)[C@H](C(N[C@H](C4=NC=CS4)CC5=CC=CC=C5)=O)C)=O)OC)[C@@H](C)CC)C)=O)=O)C)=O)C=C2)=O)=O)=O)C(C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 160 mg/mL (116.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7301 mL 3.6504 mL 7.3008 mL
5 mM 0.1460 mL 0.7301 mL 1.4602 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7301 mL 3.6504 mL 7.3008 mL 18.2520 mL
5 mM 0.1460 mL 0.7301 mL 1.4602 mL 3.6504 mL
10 mM 0.0730 mL 0.3650 mL 0.7301 mL 1.8252 mL
15 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2168 mL
20 mM 0.0365 mL 0.1825 mL 0.3650 mL 0.9126 mL
25 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL
30 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6084 mL
40 mM 0.0183 mL 0.0913 mL 0.1825 mL 0.4563 mL
50 mM 0.0146 mL 0.0730 mL 0.1460 mL 0.3650 mL
60 mM 0.0122 mL 0.0608 mL 0.1217 mL 0.3042 mL
80 mM 0.0091 mL 0.0456 mL 0.0913 mL 0.2282 mL
100 mM 0.0073 mL 0.0365 mL 0.0730 mL 0.1825 mL
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Vc-MMAD Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vc-MMAD1401963-17-4Microtubule/TubulinDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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