2. Cell Cycle/DNA Damage
  3. CDK
  4. Abemaciclib metabolite M20-d8

Abemaciclib metabolite M20-d8  (Synonyms: LSN3106726-d8)

Cat. No.: HY-129336S Purity: 97.01%
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Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

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Abemaciclib metabolite M20-d<sub>8</sub> Chemical Structure

Abemaciclib metabolite M20-d8 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Abemaciclib metabolite M20-d8:

Abemaciclib metabolite M20-d8 Related Antibodies

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Description

Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

IC50 & Target[1]

CDK4

 

CDK6

 

Molecular Weight

530.64

Formula

C27H24D8F2N8O
Appearance

Solid

Color

White to yellow

SMILES

CC(C)N1C2=CC(C3=C(C=NC(NC4=NC=C(C=C4)CN(C([2H])(C5([2H])[2H])[2H])C([2H])(C([2H])(N5CC)[2H])[2H])=N3)F)=CC(F)=C2N=C1CO
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (376.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8845 mL 9.4226 mL 18.8452 mL
5 mM 0.3769 mL 1.8845 mL 3.7690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8845 mL 9.4226 mL 18.8452 mL 47.1129 mL
5 mM 0.3769 mL 1.8845 mL 3.7690 mL 9.4226 mL
10 mM 0.1885 mL 0.9423 mL 1.8845 mL 4.7113 mL
15 mM 0.1256 mL 0.6282 mL 1.2563 mL 3.1409 mL
20 mM 0.0942 mL 0.4711 mL 0.9423 mL 2.3556 mL
25 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.8845 mL
30 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5704 mL
40 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1778 mL
50 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.9423 mL
60 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
80 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL
100 mM 0.0188 mL 0.0942 mL 0.1885 mL 0.4711 mL
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Abemaciclib metabolite M20-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abemaciclib metabolite M20-d8LSN3106726-d8CDKCyclin dependent kinasemetabolitemantle cell lymphomadeuteriumInhibitorinhibitorinhibit

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