2. Apoptosis
  3. Apoptosis
  4. ABT-510 acetate

ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD).

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ABT-510 acetate Chemical Structure

ABT-510 acetate Chemical Structure

CAS No. : 442526-87-6

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Based on 1 publication(s) in Google Scholar

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ABT-510 acetate Related Antibodies

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Description

ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD)[1][2].

In Vitro

ABT-510 acetate (1, 5, 10, 20, 50 nM; 24 h) induces apoptosis in ID8 cells and increases the incidence of apoptosis in the human epithelial cancer cell lines SKOV3, OVCAR3, and CAOV3[1].
ABT-510 acetate (0-10 μM; 7 days) inhibits NO-stimulated vascular cell outgrowth into and invasion through extracellular matrix. ABT-510 acetate blocks tumor-driven vascular cell outgrowth, NO-driven cGMP flux, and CD36-mediated fatty acid uptake. [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABT-510 acetate Related Antibodies

Apoptosis Analysis[1]

Cell Line: ID8, SKOV3, OVCAR3, and CAOV3 cells
Concentration: 1, 5, 10, 20, 50 nM
Incubation Time: 24 h
Result: Induced ID8 cells apoptosis and increased in apoptosis in the human EOC cell lines SKOV3, OVCAR3, and CAOV3.

Cell Proliferation Assay[3]

Cell Line: Tissue biopsies of B16F10 melanoma tumors grown in C57BL/6 mice
Concentration: 0-10 μM
Incubation Time: 7 days
Result: Inhibited NO-stimulated vascular cell outgrowth into and invasion through extracellular matrix.
In Vivo

ABT-510 acetate (100 mg/kg; i.p.; single daily for 90 days) induces cells apoptosis in vivo and leads to a significant reduction in epithelial ovarian tumor size, ascites fluid volume, and secondary lesion dissemination in mice[1].
ABT-510 acetate (60 mg/kg; osmotic minipumps for s.c.; single daily for 7 days) decreases angiogenesis and inflammation in a murine model of inflammatory bowel disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TSP-1-Null mice (C57BL/6 background; orthotopic, syngeneic model of epithelial ovarian cancer)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; single daily for 90 days
Result: Reduced ovarian tumor growth in wild-type and TSP-1-Null Mice.
Significantly reduced the volume of ascites and completely abolished the formation of peritoneal lesions.
Reversed ovarian tumor hypervascularization and increased the proportion of mature blood vessels.
Animal Model: TSP-1-Null mice (C57BL/6 background; 6-week-old; DSS-induced inflammatory bowel disease murine model)[2]
Dosage: 60 mg/kg
Administration: Subcutaneously implanted osmotic minipumps (0.5µL/h); single daily for 7 days
Result: Significantly delayed DSS-induced bleeding and improved the overall severity of disease.
Significantly diminished inflammation grading and angiogenesis.
Clinical Trial
Molecular Weight

1054.28

Formula

C48H87N13O13
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (94.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9485 mL 4.7426 mL 9.4851 mL
5 mM 0.1897 mL 0.9485 mL 1.8970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9485 mL 4.7426 mL 9.4851 mL 23.7129 mL
5 mM 0.1897 mL 0.9485 mL 1.8970 mL 4.7426 mL
10 mM 0.0949 mL 0.4743 mL 0.9485 mL 2.3713 mL
15 mM 0.0632 mL 0.3162 mL 0.6323 mL 1.5809 mL
20 mM 0.0474 mL 0.2371 mL 0.4743 mL 1.1856 mL
25 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9485 mL
30 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.7904 mL
40 mM 0.0237 mL 0.1186 mL 0.2371 mL 0.5928 mL
50 mM 0.0190 mL 0.0949 mL 0.1897 mL 0.4743 mL
60 mM 0.0158 mL 0.0790 mL 0.1581 mL 0.3952 mL
80 mM 0.0119 mL 0.0593 mL 0.1186 mL 0.2964 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-510442526-87-6ABT510ABT 510Apoptosisanti-angiogenic inflammationIBDID8 cancer cellsABT-510，epithelial ovarian cancerInhibitorinhibitorinhibit

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