2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 

Cat. No.: HY-P3662 Purity: 99.95%
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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.

For research use only. We do not sell to patients.

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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure

CAS No. : 82188-67-8

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5 mg USD 125 In-stock
10 mg USD 185 In-stock
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Based on 1 publication(s) in Google Scholar

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].

In Vitro

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Related Antibodies
In Vivo

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0-50 pM; i.c.v.; single dose) exerts thermoregulatory effect in rats model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model[2]
Dosage: 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline
Administration: Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection
Result: Showed greater difference than mean temperatures of animals receiving sterile saline group.
Molecular Weight

985.10

Formula

C47H64N14O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-{Nle}-EH-{d-Phe}-RWG-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (101.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0151 mL 5.0756 mL 10.1513 mL
5 mM 0.2030 mL 1.0151 mL 2.0303 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0151 mL 5.0756 mL 10.1513 mL 25.3781 mL
5 mM 0.2030 mL 1.0151 mL 2.0303 mL 5.0756 mL
10 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.5378 mL
15 mM 0.0677 mL 0.3384 mL 0.6768 mL 1.6919 mL
20 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
25 mM 0.0406 mL 0.2030 mL 0.4061 mL 1.0151 mL
30 mM 0.0338 mL 0.1692 mL 0.3384 mL 0.8459 mL
40 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6345 mL
50 mM 0.0203 mL 0.1015 mL 0.2030 mL 0.5076 mL
60 mM 0.0169 mL 0.0846 mL 0.1692 mL 0.4230 mL
80 mM 0.0127 mL 0.0634 mL 0.1269 mL 0.3172 mL
100 mM 0.0102 mL 0.0508 mL 0.1015 mL 0.2538 mL
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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH282188-67-8Tyrosinasethermoregulatory effectrats modelmelanotropinmelanocyte-stimulating hormoneInhibitorinhibitorinhibit

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