2. Immunology/Inflammation
  3. NO Synthase
  4. AE-ITU dihydrobromide

AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats.

For research use only. We do not sell to patients.

AE-ITU dihydrobromide Chemical Structure

AE-ITU dihydrobromide Chemical Structure

CAS No. : 56-10-0

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AE-ITU dihydrobromide Related Antibodies

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Description

AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats[1].

IC50 & Target

iNOS

 

In Vivo

AE-ITU dihydrobromide (1 mg/kg/h, i.v., for 1 hour) attenuates the delayed hypotension and vascular hyporeactivity, ameliorates liver dysfunction in LPS (HY-D1056)-administrated Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056)-administrated Wistar rats[1]
Dosage: 1 mg/kg
Administration: i.v., 1 mg/kg/h for 1 hour
Result: Reduced the serum levels of bilirubin, serum nitrite, GOT, GPT and γGT caused by LPS, inhibited iNOS in lung and liver homogenates.
Molecular Weight

281.01

Formula

C3H11Br2N3S
CAS No.
Appearance

Solid

SMILES

NC(SCCN)=N.[H]Br.[H]Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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AE-ITU dihydrobromide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AE-ITU dihydrobromide56-10-0NO SynthaseNitric oxide synthasesNOSWistar ratsInhibitorinhibitorinhibit

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