ALK/HDAC-IN-1

Cat. No.: HY-161350: FAQs
Data Sheet Handling Instructions

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ALK/HDAC-IN-1 is a dual inhibitor for ALK and HADC6, with IC₅₀s of 16 nM and 1.03 μM, respectively. ALK/HDAC-IN-1 exhibits antitumor activity.

For research use only. We do not sell to patients.

ALK/HDAC-IN-1 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

ALK/HDAC-IN-1 is a dual inhibitor for ALK and HADC6, with IC₅₀s of 16 nM and 1.03 μM, respectively. ALK/HDAC-IN-1 exhibits antitumor activity^[1].

IC₅₀ & Target

HDAC6

1.03 μM (IC₅₀)

HDAC8

1.69 μM (IC₅₀)

HDAC1

10.8 μM (IC₅₀)

HDAC11

16.6 μM (IC₅₀)

In Vitro

ALK/HDAC-IN-1 inihibits proliferations of cancer cells A549, HepG2, MCF7, U87MG and H2228, with IC₅₀s of 0.33, 0.59, 0.55, 0.62 and 0.44 μM, respectively^[1].
ALK/HDAC-IN-1 inihibits CYP450 enzymes CYP2C9 with IC₅₀ of 2.65 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	A549, HepG2, MCF7, U87MG and H2228
Concentration:
Incubation Time:	48 h
Result:	Inhibited proliferations with sub-micromolar level IC50 values.

Western Blot Analysis^[1]

Cell Line:	H2228
Concentration:	2 μM
Incubation Time:	6 h
Result:	Ptomoted acetylation of α-tubulin and histone H3.

In Vivo

ALK/HDAC-IN-1 (0-20 mg/kg, i.p. for 21 days) inhibits tumor growth without significant toxicity in A549 xenografted BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A549 xenografted BALB/c mice^[1]
Dosage:	0-20 mg/kg
Administration:	i.p., once daily for 21 days
Result:	Decrease tumor growth with TGIs of 68% and 85%, with dose of 10 and 20 mg/kg, respectively.

Molecular Weight

489.57

Formula

C₂₇H₃₁N₅O₄

SMILES

O=C(/N=C1N([C@@H]2CC[C@H](C(NC(C)C)=O)CC2)C3=CC=C(/C=C/C(NO)=O)C=C3N/1)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang KL, et al., Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2318645. [Content Brief]

ALK/HDAC-IN-1 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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