Alosetron Hydrochloride (Synonyms: GR 68755C; GR 68755 Hydrochloride; GR 68755X Hydrochloride)

Cat. No.: HY-70050C Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

For research use only. We do not sell to patients.

Alosetron Hydrochloride Chemical Structure

CAS No. : 122852-69-1

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 56	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 56	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 51	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 175	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of Alosetron Hydrochloride:

Alosetron-d₃ hydrochloride In-stock
Alosetron (Hydrochloride(1:X)) Get quote
Alosetron Get quote
Alosetron-d₃ Get quote
Alosetron ((Z)-2-butenedioate) Get quote

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•Related Screening Libraries:

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View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

5-HT₃ Receptor

In Vivo

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

330.81

Formula

C₁₇H₁₉ClN₄O

CAS No.

122852-69-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (100.75 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0229 mL	15.1144 mL	30.2288 mL
5 mM	0.6046 mL	3.0229 mL	6.0458 mL
10 mM	0.3023 mL	1.5114 mL	3.0229 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (276 KB) SDS (419 KB)

COA (253 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74.

[2]. Lucak SL. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72. [Content Brief]

[3]. Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. [Content Brief]

[4]. Turgeon DK, Tayeh N, Fontana RJ. Acute hepatitis associated with alosetron (Lotronex). J Clin Gastroenterol. 2005 Aug;39(7):641-2. [Content Brief]

[5]. Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM. Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride. Am J Gastroenterol. 2003 May;98(5):1117-22. [Content Brief]

[6]. Balfour JA, Goa KL, Perry CM. Alosetron. Drugs. 2000;59(3):511-520. [Content Brief]

[7]. Motavallian A, et al. Anti-inflammatory effects of alosetron mediated through 5-HT3 receptors on experimental colitis. Res Pharm Sci. 2019;14(3):228-236. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.0229 mL	15.1144 mL	30.2288 mL	75.5721 mL
	5 mM	0.6046 mL	3.0229 mL	6.0458 mL	15.1144 mL
	10 mM	0.3023 mL	1.5114 mL	3.0229 mL	7.5572 mL
	15 mM	0.2015 mL	1.0076 mL	2.0153 mL	5.0381 mL
	20 mM	0.1511 mL	0.7557 mL	1.5114 mL	3.7786 mL
	25 mM	0.1209 mL	0.6046 mL	1.2092 mL	3.0229 mL
	30 mM	0.1008 mL	0.5038 mL	1.0076 mL	2.5191 mL
	40 mM	0.0756 mL	0.3779 mL	0.7557 mL	1.8893 mL
	50 mM	0.0605 mL	0.3023 mL	0.6046 mL	1.5114 mL
	60 mM	0.0504 mL	0.2519 mL	0.5038 mL	1.2595 mL
	80 mM	0.0378 mL	0.1889 mL	0.3779 mL	0.9447 mL
	100 mM	0.0302 mL	0.1511 mL	0.3023 mL	0.7557 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Alosetron Hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alosetron122852-69-1GR 68755CGR 68755GR 68755XGR68755GR-687555-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectivedepolarizationvisceralnociceptivecolitisInhibitorinhibitorinhibit

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