Aminoethyl-SS-propionic acid

Name: Aminoethyl-SS-propionic acid
Brand: MedChemExpress
SKU: HY-140096
Rating: 4.5 (1 reviews)

Cat. No.: HY-140096: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Aminoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Aminoethyl-SS-propionic acid Chemical Structure

CAS No. : 15579-00-7

Size	Price	Stock	Quantity
5 mg	USD 77	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 410	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Aminoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

181.28

Formula

C₅H₁₁NO₂S₂

CAS No.

15579-00-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCSSCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (689.54 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5163 mL	27.5816 mL	55.1633 mL
5 mM	1.1033 mL	5.5163 mL	11.0327 mL
10 mM	0.5516 mL	2.7582 mL	5.5163 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 11.11 mg/mL (61.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (241 KB) HNMR (214 KB) LCMS (249 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.5163 mL	27.5816 mL	55.1633 mL	137.9082 mL
	5 mM	1.1033 mL	5.5163 mL	11.0327 mL	27.5816 mL
	10 mM	0.5516 mL	2.7582 mL	5.5163 mL	13.7908 mL
	15 mM	0.3678 mL	1.8388 mL	3.6776 mL	9.1939 mL
	20 mM	0.2758 mL	1.3791 mL	2.7582 mL	6.8954 mL
	25 mM	0.2207 mL	1.1033 mL	2.2065 mL	5.5163 mL
	30 mM	0.1839 mL	0.9194 mL	1.8388 mL	4.5969 mL
	40 mM	0.1379 mL	0.6895 mL	1.3791 mL	3.4477 mL
	50 mM	0.1103 mL	0.5516 mL	1.1033 mL	2.7582 mL
	60 mM	0.0919 mL	0.4597 mL	0.9194 mL	2.2985 mL
	80 mM	0.0690 mL	0.3448 mL	0.6895 mL	1.7239 mL
	100 mM	0.0552 mL	0.2758 mL	0.5516 mL	1.3791 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.