2. Induced Disease Models Products GPCR/G Protein Apoptosis
  3. Cardiovascular System Disease Models Angiotensin Receptor Apoptosis
  4. Hypertension Models
  5. Angiotensin II human acetate

Angiotensin II human acetate  (Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate)

Cat. No.: HY-13948A Purity: 99.79%
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Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II human acetate Chemical Structure

Angiotensin II human acetate Chemical Structure

CAS No. : 68521-88-0

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
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Based on 97 publication(s) in Google Scholar

Other Forms of Angiotensin II human acetate:

Angiotensin II human acetate Related Antibodies

Top Publications Citing Use of Products

93 Publications Citing Use of MCE Angiotensin II human acetate

RT-PCR
WB

    Angiotensin II human acetate purchased from MedChemExpress. Usage Cited in: Mol Cell Endocrinol. 2023 Apr 24;111938.  [Abstract]

    Angiotensin II human (Ang II; 1 μM; 48 h) increases the expression of MFN1, t-CaMKⅡ and p-CaMKⅡ and decreases the expression of SERCA2 in NMCMs.

    Angiotensin II human acetate purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022, 10(12), 3131.

    Angiotensin II human (Ang II; 100 nM; 24 h) pretreatment significantly increases both the mRNA level of CtBP1 during 3T3-L1 adipogenesis.

    Angiotensin II human acetate purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022, 10(12), 3131.

    Angiotensin II human (Ang II; 100 nM; 24 h) pretreatment significantly increases both the protein level of CtBP1 during 3T3-L1 adipogenesis.

    Angiotensin II human acetate purchased from MedChemExpress. Usage Cited in: Int J Biochem Cell Biol. 2020 Apr;121:105703.  [Abstract]

    HPMCs are treated with 5.6 mM glucose (NG) or with 236 mM glucose (HG), or 100 nM AngII (AngII), or 236 mM glucose plus 10 mM valsartan (HGþvalsartan), or 100 nM AngII plus 10 mM valsartan (AngIIþvalsartan) for 24 h. The protein levels of p-mTOR, mTOR, p-4EBP1, 4EBP1, p-S6K1, and S6K1 are examined by Western blot analysis.

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    • Biological Activity

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    • References

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    Description

    Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].

    IC50 & Target

    AT2 Receptor

     

    AT1 Receptor

     

    In Vitro

    Most of the known actions of Angiotensin II (Ang II) human acetate are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1].
    Angiotensin II human acetate raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II human acetate actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2].
    Angiotensin II (1 nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Matrigel assay. Angiotensin II -mediated expression of LOX-1 and VEGF, capillary formation, intracellular reactive oxygen species generation, and phosphorylation of p38 as well as p44/42 mitogen-activated protein kinases, were suppressed by anti-LOX-1 antibody, nicotinamide-adenine dinucleotide phosphate oxidase inhibitor apocynin and the Ang II type 1 receptor blocker Losartan, but not by the Ang II type 2 receptor blocker PD123319[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Angiotensin II human acetate Related Antibodies
    In Vivo

    Angiotensin II human (5 mL of 1 nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) acetate induces a significant neutrophil recruitment that was maximal at 4 hours and had resolved by 24 hours[4].
    To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II human (1000 ng/kg/min) acetate continuously for 4 weeks. Angiotensin II human acetate causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[5].
    1. Induction of hypertension[7]
    Background
    Specific Mmodeling Methods
    Mice: C57/BL6J • male and female • 12-16 wk old • 21-27 g
    Administration: 800 ng/kg/min, 0.003 mL/min • 7 days • sc, osmotic pump implanted subcutaneously
    Note
    Effect of gender: Chronic ANG II-induced hypertension differs by gender in awake mice. Female mice may be protected from the ANG II-induced increase in blood pressure.


    Modeling Indicators
    Key Factor: Blood pressure ↑ on day 7, blood pressure in male was greater than in female.
    Opposite Product(s):
    2. Induction of Cardiac Hypertrophy[8][9]
    Background
    Specific Mmodeling Methods
    Mice: C57/BL6J • male • 8 wk old &bull
    Administration: 2 μg/kg/min • 4 weeks • sc, osmotic pump implanted subcutaneously


    Modeling Indicators
    Indicator changes: Blood pressure in WT mice increased significantly.
    Appearance monitoring: cardiac hypertrophy and fibrosis.
    Opposite Product(s): Eplerenone (HY-B0251)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    1106.23

    Formula

    C52H75N13O14
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
    Sequence Shortening

    DRVYIHPF
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light, under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (22.60 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9040 mL 4.5199 mL 9.0397 mL
    5 mM 0.1808 mL 0.9040 mL 1.8079 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (9.04 mM); Clear solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  Saline

      Solubility: 16.67 mg/mL (15.07 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.79%

    COA (257 KB) LCMS (258 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.9040 mL 4.5199 mL 9.0397 mL 22.5993 mL
    5 mM 0.1808 mL 0.9040 mL 1.8079 mL 4.5199 mL
    10 mM 0.0904 mL 0.4520 mL 0.9040 mL 2.2599 mL
    15 mM 0.0603 mL 0.3013 mL 0.6026 mL 1.5066 mL
    20 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1300 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Angiotensin II human acetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Angiotensin II human68521-88-0Angiotensin IIAng IIDRVYIHPFAngiotensin ReceptorApoptosisInhibitorinhibitorinhibit

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