2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. PPAR Apoptosis
  4. Ankaflavin

Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.

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Ankaflavin Chemical Structure

Ankaflavin Chemical Structure

CAS No. : 50980-32-0

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Based on 1 publication(s) in Google Scholar

Ankaflavin Related Antibodies

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Description

Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects[1][2].

IC50 & Target

PPARγ[2].
In Vitro

Ankaflavin (0-50 µg/mL, 48 h) shows cytotoxicity against cancer cells with no significant toxicity toward normal cells[1].
Ankaflavin (0-30 µg/mL, 0-48 h) arrests Hep G2 cell cycle at sub-G1 phase in a dose- and time-dependent manner[1].
Ankaflavin (25 µg/mL, 48 h) induces Hep G2 cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ankaflavin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, Hep G2, MRC-5 and WI-38
Concentration: 1, 10, 25, and 50 µg/mL
Incubation Time: 48 h
Result: Showed cytotoxicity against A549 and Hep G2 cells in a dose-dependent manner with no significant toxicity toward normal cells (MRC-5 and WI-38).

Cell Cycle Analysis[1]

Cell Line: Hep G2 cells
Concentration: 15, 20, 25, and 30 µg/mL
Incubation Time: 12, 24, 36, and 48 h
Result: Induced a distinct sub-G1 peak in Hep G2 cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: Hep G2 cells
Concentration: 25 µg/mL
Incubation Time: 48 h
Result: Exhibited significant chromatin condensation (fluorescent spot) through Hoechst staining.
In Vivo

Ankaflavin (10 mg/kg; p.o.; daily for 28 days) shows antidiabetic and anti-inflammatory activity, improves liver function and pancreatic function[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (4 weeks of age), diabetes was induced by treating them with Methylglyoxal (MG) (600 mg/kg; oral) for 4 weeks[2]
Dosage: 10 mg/kg
Administration: Oral administration for 28 days
Result: Exerted PPARγ agonist activity. Effectively reduced AGE (advanced glycation end-products) levels in serum, liver, and pancreas of MG-induced rats.
Molecular Weight

386.48

Formula

C23H30O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@@H]1C(CCCCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O
Structure Classification
Initial Source

Monascus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 98.33%

COA (251 KB)

Handling Instructions (2659 KB)
References
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Ankaflavin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ankaflavin50980-32-0PPARApoptosisPeroxisome proliferator-activated receptorsHep G2A549anticancerantioxidantantidiabeticanti-inflammatoryantiatherosclerotichypolipidemic effectInhibitorinhibitorinhibit

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