2. Immunology/Inflammation Apoptosis
  3. TNF Receptor Interleukin Related
  4. Anti-inflammatory agent 17

Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI).

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Anti-inflammatory agent 17 Chemical Structure

Anti-inflammatory agent 17 Chemical Structure

CAS No. : 2763226-84-0

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Anti-inflammatory agent 17 Related Antibodies

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Description

Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1].

IC50 & Target

TNF-α

2.576 μM (IC50)

IL-6

8.254 μM (IC50)

In Vitro

Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells[1].
Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 17 Related Antibodies

Cell Viability Assay[1]

Cell Line: J774a.1 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Displayed no toxicity in J774a.1 cells.

Immunofluorescence[1]

Cell Line: J774A.1 cells
Concentration: 1.25, 2.5, 5, 10 µM
Incubation Time: 2 h
Result: Inhibited the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner.
In Vivo

Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[1]
Dosage: 20 mg/kg
Administration: Intragastric administration
Result: Exhibited protective effect on LPS-induced ALI in mice.
Molecular Weight

357.40

Formula

C20H23NO5
CAS No.
SMILES

CN(CCCOC1=CC=C(C(C(/C=C/C2=CC(O)=C(C=C2)O)=O)=C1)O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 172763226-84-0TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILanti-inflammatoryAcute lung injury (ALI)lipopolysaccharideJ774a.1 cellsTNF-αIL-6cytotoxicityInhibitorinhibitorinhibit

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