Antibacterial agent 207 

Antibacterial agent 207 (Compound Ru1) has antibacterial activity against S. aureus (MIC: 1 μg/mL), and low resistance frequencies. Antibacterial agent 207 destroys the bacterial cell membrane, promote production of ROS in bacteria^[1].

Antibacterial agent 207 (1 and 2 μg/mL) shows damage on bacterial membrane of S. aureus (PI staining), and induces release of β-galactosidase^[1].
Antibacterial agent 207 (1 and 2 μg/mL, 2 h) cause a range of oxidative stress damage, induces ROS in S. aureus^[1].
Antibacterial agent 207 (0.25 or 0.5 μg/mL, 48 h) inhibit the secretion of α-toxin and bacterial biofilm formation in S. aureus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 207 (5 mg/kg, 5 μL, injected at the right gastropoda) shows anti-infective effect and increases survival in G. mellonella infected with S. aureus^[1].
Antibacterial agent 207 (100 μg/mL, applied to the wound, twice a day) has robust anti-infective efficacy against S. aureus in mice skin infected with S. aureus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1340.15

C₆₁H₅₆F₁₂N₈O₃P₂Ru

O=C(OCCC1(CC2C3)CC3CC(C2)C1)CCCOC(C=C4)=CC=C4C(N5C6=CC=CC=C6)=NC7=C5C8=C(C9=C7C=CC=[N]9%10)[N]([Ru+2]%11%12%10([N]%13=CC=CC=C%13C%14=[N]%12C=CC=C%14)[N]%15=C(C%16=CC=CC=[N]%16%11)C=CC=C%15)=CC=C8.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang L, et al. Design, synthesis, anti-infective potency and mechanism study of novel Ru-based complexes containing substituted adamantane as antibacterial agents. Eur J Med Chem. 2024 Apr 2;270:116378.  [Content Brief]