2. Metabolic Enzyme/Protease Anti-infection
  3. Mitochondrial Metabolism Parasite
  4. Antimalarial agent 14

Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent.

For research use only. We do not sell to patients.

Antimalarial agent 14 Chemical Structure

Antimalarial agent 14 Chemical Structure

CAS No. : 1150-59-0

Size Price Stock Quantity
5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 620 In-stock
50 mg USD 860 In-stock
100 mg USD 1150 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Antimalarial agent 14 Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent[1].

IC50 & Target

Plasmodium

 

In Vitro

Antimalarial agent 14 (Compound N3) (0-400 μM, 48 h) inhibits P. falciparum with limited cytotoxicity against human cells[1].
Antimalarial agent 14 inhibits P. falciparum mitochondrial membrane potential with an IC50ΔΨmit of 16 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 14 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: P. falciparum and HEK293T
Concentration: 0.128, 0.64, 3.2, 16, 80 and 400 μM
Incubation Time: 48 h
Result: Showed inhibition with an IC50 of 443 nM against P. falciparum and showed cytotoxicity with a CC50 of 54.6 ± 0.23 μM.
Molecular Weight

250.25

Formula

C16H10O3
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1C(O)=C(C2=CC=CC=C2)C(C3=C1C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (499.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9960 mL 19.9800 mL 39.9600 mL
5 mM 0.7992 mL 3.9960 mL 7.9920 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9960 mL 19.9800 mL 39.9600 mL 99.9001 mL
5 mM 0.7992 mL 3.9960 mL 7.9920 mL 19.9800 mL
10 mM 0.3996 mL 1.9980 mL 3.9960 mL 9.9900 mL
15 mM 0.2664 mL 1.3320 mL 2.6640 mL 6.6600 mL
20 mM 0.1998 mL 0.9990 mL 1.9980 mL 4.9950 mL
25 mM 0.1598 mL 0.7992 mL 1.5984 mL 3.9960 mL
30 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3300 mL
40 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4975 mL
50 mM 0.0799 mL 0.3996 mL 0.7992 mL 1.9980 mL
60 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6650 mL
80 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2488 mL
100 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9990 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antimalarial agent 14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 141150-59-0Antimalarial agent14Antimalarial agent-14Mitochondrial MetabolismParasitelow cytotoxicityP. falciparummitochondrial electron transportInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antimalarial agent 14
Cat. No.:
HY-114197
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.