2. GPCR/G Protein
  3. CRFR
  4. Antisauvagine-30 TFA

Antisauvagine-30 TFA  (Synonyms: aSvg-30 TFA)

Cat. No.: HY-P1107A Purity: 98.10%
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Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

For research use only. We do not sell to patients.

Antisauvagine-30 TFA Chemical Structure

Antisauvagine-30 TFA Chemical Structure

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5 mg USD 320 In-stock
10 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Antisauvagine-30 TFA:

Antisauvagine-30 TFA Related Antibodies

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  • Biological Activity

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Description

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively[1][2][3][4].

IC50 & Target

Kd: 1.4 nM (mCRFR2β), 150 nM (CRFR1).
In Vitro

Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antisauvagine-30 TFA Related Antibodies
In Vivo

Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2].
Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nine-week-old male BALB/c mice[2].
Dosage: 400 ng/0.5 μl per mouse.
Administration: Administered bilaterally by a microinjector (intrahippocampal (i.h.) injection).
Result: Prevented the stress-induced enhancement of fear conditioning.
Molecular Weight

3764.28

Formula

C163H275N48F3O49S
Appearance

Solid

Color

White to off-white

Sequence Shortening

{D-Phe}-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2
SMILES

[(D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2 (TFA salt)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (26.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 25 mg/mL (6.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2657 mL 1.3283 mL 2.6566 mL
5 mM 0.0531 mL 0.2657 mL 0.5313 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.2657 mL 1.3283 mL 2.6566 mL 6.6414 mL
5 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.3283 mL
DMSO 10 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.6641 mL
15 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.4428 mL
20 mM 0.0133 mL 0.0664 mL 0.1328 mL 0.3321 mL
25 mM 0.0106 mL 0.0531 mL 0.1063 mL 0.2657 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Antisauvagine-30 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antisauvagine-30aSvg-30Antisauvagine30Antisauvagine 30aSvg30aSvg 30CRFRCorticotropin-releasing Factor ReceptorCRHRstressfearmemoryanxiogenicInhibitorinhibitorinhibit

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