Antitumor photosensitizer-4 

Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells^[1].

Antitumor photosensitizer-4 arrests cell cycle at S phase,

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor photosensitizer-4 () inhibits tumor growth and prolong survival time on BALB/c nude mice bearing HepG2 xenograft tumor.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1269.90

C₆₅H₇₇ClN₁₂O₁₁S

CC1=C(/C=C2[C@@H](C)[C@H](CCC(O)=O)C3=N/2)NC(/C=C4C(C)=C(CC)C(/C=C(N/5)/C(C)=C(C(O)=O)C5=C3/CC(NCCOCCOCCOCCC(OCCN6CCN(C7=CC(NC8=NC=C(C(NC9=C(C)C=CC=C9Cl)=O)S8)=NC(C)=N7)CC6)=O)=O)=N/4)=C1C=C

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• [1]. Huang F, et al. Novel chlorin e6-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy. Eur J Med Chem. 2023 Sep 5;261:115787.. .  [Content Brief]