2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. ARC19499 sodium

ARC19499 sodium  (Synonyms: BAX499 sodium)

Cat. No.: HY-153480A Purity: 93.65%
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ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

For research use only. We do not sell to patients.

RNA, (Gm-Gm-Am-Am-Um-Am-Um-Am-dC-Um-Um-Gm-Gm-dC-Um-dC-Gm-Um-Um-Am-Gm-Gm-Um-Gm-dC-Gm-Um-Am-Um-Am-Um-Am-(3′→3′)-dT), 5′-(6-aminohexyl hydrogen phosphate), sodium salt

ARC19499 sodium Chemical Structure

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1 mg USD 330 In-stock
5 mg USD 980 In-stock
10 mg USD 1610 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

ARC19499 sodium Related Antibodies

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Description

ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

Molecular Weight

11837.60

Appearance

Solid

Color

White to off-white

SMILES

[ARC19499 (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
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ARC19499 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARC19499BAX499ARC 19499ARC-19499BAX 499BAX-499Factor XaFxaInhibitorinhibitorinhibit

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ARC19499 sodium
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