2. Immunology/Inflammation
  3. NO Synthase
  4. ARL 17477

ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers.

For research use only. We do not sell to patients.

ARL 17477 Chemical Structure

ARL 17477 Chemical Structure

CAS No. : 866914-87-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in DMSO USD 143 In-stock
Solid
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 460 In-stock
50 mg USD 740 In-stock
100 mg USD 1200 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers[1].

Molecular Weight

442.83

Formula

C20H22Cl3N3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (141.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (45.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2582 mL 11.2910 mL 22.5820 mL
5 mM 0.4516 mL 2.2582 mL 4.5164 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.2582 mL 11.2910 mL 22.5820 mL 56.4551 mL
5 mM 0.4516 mL 2.2582 mL 4.5164 mL 11.2910 mL
10 mM 0.2258 mL 1.1291 mL 2.2582 mL 5.6455 mL
15 mM 0.1505 mL 0.7527 mL 1.5055 mL 3.7637 mL
20 mM 0.1129 mL 0.5646 mL 1.1291 mL 2.8228 mL
25 mM 0.0903 mL 0.4516 mL 0.9033 mL 2.2582 mL
30 mM 0.0753 mL 0.3764 mL 0.7527 mL 1.8818 mL
40 mM 0.0565 mL 0.2823 mL 0.5646 mL 1.4114 mL
DMSO 50 mM 0.0452 mL 0.2258 mL 0.4516 mL 1.1291 mL
60 mM 0.0376 mL 0.1882 mL 0.3764 mL 0.9409 mL
80 mM 0.0282 mL 0.1411 mL 0.2823 mL 0.7057 mL
100 mM 0.0226 mL 0.1129 mL 0.2258 mL 0.5646 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ARL 17477 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARL 17477866914-87-6ARL17477ARL-17477NO SynthaseNitric oxide synthasesNOSNOS1,autophagy,anticancerInhibitorinhibitorinhibit

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