ASP6918

Cat. No.: HY-162249: FAQs
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ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC₅₀ value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity.

For research use only. We do not sell to patients.

ASP6918 Chemical Structure

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Biological Activity
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References
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Description

ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC₅₀ value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity^[1].

IC₅₀ & Target^[1]

KRas G12C

0.028 μM (IC₅₀)

In Vitro

ASP6918 (compound 29a) (6 days) inhibits cell growth with an IC₅₀ value of 0.0061 µM for NCI-H1373 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	NCI-H1373 cells
Concentration:
Incubation Time:	6 days
Result:	Inhibited cell growth with an IC₅₀ value of 0.0061 µM.

In Vivo

ASP6918 (10, 20, 40, 60 mg/kg; p.o.; daily for 13 days) shows antitumor activity in NCI-H1373 xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Four-week-old male nude mice (NCI-H1373 xenograft mouse model)^[1]
Dosage:	10, 20, 40, 60 mg/kg
Administration:	Oral, daily for 13 days
Result:	Inhibited of tumor growth with tumor growth inhibition (TGI) rate of 27%, 68%, 49%, 73% at 10, 20, 40, 60 mg/kg.

Molecular Weight

621.77

Formula

C₃₆H₄₃N₇O₃

SMILES

C=CC1=CC2=C(N=C(OC3CCN(C)CC3)N=C2N4CCC5(CN(C(C=C)=O)C5)CC4)C(OCC)=[C@]1[C@]6=C(C)C=CC7=C6C=NN7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Imaizumi T, et al. Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors. Bioorg Med Chem. 2024 Jan 15;98:117581. [Content Brief]

ASP6918 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP6918ASP 6918ASP-6918RasNCI-H1373 cellsoral activityantitumorInhibitorinhibitorinhibit

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