2. Apoptosis
  3. RIP kinase
  4. AV123

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.

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AV123 Chemical Structure

AV123 Chemical Structure

CAS No. : 233605-81-7

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AV123 Related Antibodies

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Description

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].

IC50 & Target

IC50: 0.48 µM (CDK9/ CyclinT), 0.80 µM (CLK1 of Mus musculus), 1.80 µM (DYRK1A of Rattus norvegicus), >10 µM (CDK2/CyclinA, CDK5/p25, HASPIN, Pim1, CK1 ε, JAK3, ABL1, RIPK3, AURKB)[1].
In Vitro

AV123 (0.01-100 µM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells[1].
AV123 (0.01-50 µM; 24 h) shows no toxicity to RPE-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AV123 Related Antibodies

Cell Viability Assay[1]

Cell Line: FADD-deficient Jurkat cells
Concentration: 0.01-100 µM
Incubation Time: 24 h
Result: Significantly blocked the necroptotic cell-death induced by TNF-α with an EC50 value of 1.7 µM.

Cell Cytotoxicity Assay[1]

Cell Line: RPE-1 cells
Concentration: 0.01-50 µM
Incubation Time: 24 h
Result: Exhibited no toxicity to RPE-1 cells.
Molecular Weight

234.25

Formula

C11H14N4O2
CAS No.
SMILES

O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AV123 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV123233605-81-7AV 123AV-123RIP kinaseReceptor-interacting protein kinasesRIPKnecroptosisFADD-deficient Jurkat cellsRPE-1 cellsRCDInhibitorinhibitorinhibit

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