Bacitracin Zinc (Synonyms: Zinc bacitracin)

Cat. No.: HY-B0278 Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bacitracin Zinc (Zinc bacitracin) is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.

For research use only. We do not sell to patients.

Bacitracin Zinc Chemical Structure

CAS No. : 1405-89-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biological Activity
Purity & Documentation
References
Customer Review

Description

Bacitracin Zinc (Zinc bacitracin) is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM. Target: Antibacterial Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis [1, 2].

Molecular Weight

1486.06

Formula

C₆₆H₁₀₁N₁₇O₁₆SZn

CAS No.

1405-89-6

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](NC([C@@H](CCCN)NC([C@H](CCCCNC1=O)NC([C@H]([C@@H](C)CC)NC([C@@H](CCC([O-])=O)NC([C@@H](NC(C2CSC(C(C(CC)C)N)=N2)=O)CC(C)C)=O)=O)=O)=O)=O)[C@H](C)CC)N[C@@H](C(N[C@H](CC3=CN=CN3)C(N[C@H](CC([O-])=O)C(N[C@H]1CC(N)=O)=O)=O)=O)CC4=CC=CC=C4.[Zn+2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

1M HCl : 50 mg/mL (33.65 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6729 mL	3.3646 mL	6.7292 mL
5 mM	0.1346 mL	0.6729 mL	1.3458 mL
10 mM	0.0673 mL	0.3365 mL	0.6729 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (257 KB) LCMS (131 KB)

Handling Instructions (2659 KB)

References

[1]. Murphy, T., et al., Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. J Biotechnol, 2007. 131(4): p. 397-403. [Content Brief]

[2]. Karala, A.R. and L.W. Ruddock, Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J, 2010. 277(11): p. 2454-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

1M HCl	1 mM	0.6729 mL	3.3646 mL	6.7292 mL	16.8230 mL
	5 mM	0.1346 mL	0.6729 mL	1.3458 mL	3.3646 mL
	10 mM	0.0673 mL	0.3365 mL	0.6729 mL	1.6823 mL
	15 mM	0.0449 mL	0.2243 mL	0.4486 mL	1.1215 mL
	20 mM	0.0336 mL	0.1682 mL	0.3365 mL	0.8412 mL
	25 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.6729 mL
	30 mM	0.0224 mL	0.1122 mL	0.2243 mL	0.5608 mL

Bacitracin Zinc Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bacitracin1405-89-6Zinc bacitracinBacterialAntibioticInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks