BIIL-260 hydrochloride

Name: BIIL-260 hydrochloride
Brand: MedChemExpress
SKU: HY-114641A
Rating: 4.5 (1 reviews)

Cat. No.: HY-114641A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with K_i values of 1.7 nM.

For research use only. We do not sell to patients.

BIIL-260 hydrochloride Chemical Structure

CAS No. : 192581-24-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 332	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 332	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1440	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

LTB₄

1.7 nM (Ki)

In Vitro

BIIL-260 hydrochloride potently inhibits LTB₄-induced intracellular Ca²⁺ release in human neutrophils with IC₅₀ value of 0.82 nM

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

503.03

Formula

C₃₀H₃₁ClN₂O₃

CAS No.

192581-24-1

Appearance

Solid

Color

White to off-white

SMILES

N=C(C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1)N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (248.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9880 mL	9.9398 mL	19.8795 mL
5 mM	0.3976 mL	1.9880 mL	3.9759 mL
10 mM	0.1988 mL	0.9940 mL	1.9880 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) RP-HPLC (209 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9880 mL	9.9398 mL	19.8795 mL	49.6988 mL
	5 mM	0.3976 mL	1.9880 mL	3.9759 mL	9.9398 mL
	10 mM	0.1988 mL	0.9940 mL	1.9880 mL	4.9699 mL
	15 mM	0.1325 mL	0.6627 mL	1.3253 mL	3.3133 mL
	20 mM	0.0994 mL	0.4970 mL	0.9940 mL	2.4849 mL
	25 mM	0.0795 mL	0.3976 mL	0.7952 mL	1.9880 mL
	30 mM	0.0663 mL	0.3313 mL	0.6627 mL	1.6566 mL
	40 mM	0.0497 mL	0.2485 mL	0.4970 mL	1.2425 mL
	50 mM	0.0398 mL	0.1988 mL	0.3976 mL	0.9940 mL
	60 mM	0.0331 mL	0.1657 mL	0.3313 mL	0.8283 mL
	80 mM	0.0248 mL	0.1242 mL	0.2485 mL	0.6212 mL
	100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.4970 mL