Mitochondrial import receptor subunit TOM7 homolog

Definition:

Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

References:

[1]. Samuel A Hasson, et al. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature. 2013 Dec 12;504(7479):291-5. [Content Brief]

[2]. Hiroki Kato, et al. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Biochem Biophys Res Commun. 2008 May 9;369(3):958-63. [Content Brief]

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