Palmitoyltransferase ZDHHC18

Definition:

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.

References:

[1]. Chengrui Shi, et al. ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation. EMBO J. 2022 Jun 1;41(11):e109272. [Content Brief]

[2]. Yusuke Ohno, et al. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Mol Biol Cell. 2012 Dec;23(23):4543-51. [Content Brief]

[3]. Naoko Adachi, et al. S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. J Biol Chem. 2016 Sep 16;291(38):20232-46. [Content Brief]

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