Pantetheinase

Definition:

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

References:

[1]. B Maras, et al. Is pantetheinase the actual identity of mouse and human vanin-1 proteins?. FEBS Lett. 1999 Nov 19;461(3):149-52. [Content Brief]

[2]. F Martin, et al. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics. 2001 May-Jun;53(4):296-306. [Content Brief]

[3]. Ykelien L Boersma, et al. The structure of vanin 1: a key enzyme linking metabolic disease and inflammation. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3320-9. [Content Brief]

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