Pantothenate kinase 1

Definition:

[Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.

References:

[1]. Gayathri Ramaswamy, et al. PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression. J Lipid Res. 2004 Jan;45(1):17-31. [Content Brief]

[2]. Bum Soo Hong, et al. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem. 2007 Sep 21;282(38):27984-93. [Content Brief]

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