PCNA-associated factor

Definition:

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.

References:

[1]. Zeina Kais, et al. KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res. 2011 Aug;9(8):1091-9. [Content Brief]

[2]. Lou K Povlsen, et al. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol. 2012 Oct;14(10):1089-98. [Content Brief]

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