PCNA-interacting partner

Definition:

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

References:

[1]. George-Lucian Moldovan, et al. Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell. 2012 Jan 13;45(1):75-86. [Content Brief]

[2]. Lianhua Piao, et al. C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. Genes Chromosomes Cancer. 2011 Jan;50(1):13-24. [Content Brief]

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