Peroxiredoxin-like 2A

Definition:

Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.

References:

[1]. Yan Xu, et al. PAMM: a redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal. 2010 Jul 1;13(1):27-37. [Content Brief]

[2]. Fang Guo, et al. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. Biochem J. 2015 Dec 15;472(3):309-18. [Content Brief]

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