Phosphatidylinositol 4-kinase type 2-alpha

Definition:

Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

References:

[1]. Adriana Baumlova, et al. The crystal structure of the phosphatidylinositol 4-kinase IIα. EMBO Rep. 2014 Oct;15(10):1085-92. [Content Brief]

[2]. Qiangjun Zhou, et al. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat Commun. 2014 Mar 28;5:3552. [Content Brief]

[3]. S Minogue, et al. Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family. J Biol Chem. 2001 May 18;276(20):16635-40. [Content Brief]

[4]. Julia Mössinger, et al. Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. EMBO Rep. 2012 Dec;13(12):1087-94. [Content Brief]

[5]. Shane Minogue, et al. Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor. J Cell Sci. 2006 Feb 1;119(Pt 3):571-81. [Content Brief]

[6]. Shane Minogue, et al. Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res. 2010 Aug;51(8):2314-24. [Content Brief]

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