Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Definition:

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.

References:

[1]. Diana G Wang, et al. PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Rep. 2019 May 14;27(7):1991-2001.e5. [Content Brief]

[2]. Kazutaka Sumita, et al. The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. Mol Cell. 2016 Jan 21;61(2):187-98. [Content Brief]

[3]. A M Castellino, et al. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1997 Feb 28;272(9):5861-70. [Content Brief]

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