Phosphodiesterase type 5 (PDE-5)

Definition:

Phosphodiesterase type 5 (PDE-5) is the major cGMP hydrolyzing enzyme in penile corpus cavernosum and is an important regulator of nitric oxide-mediated smooth muscle relaxation.

References:

[1]. N N Kim, et al. Phosphodiesterase type 5 inhibitors: a biochemical and clinical correlation survey. Int J Impot Res. 2003 Oct;15 Suppl 5:S13-9. [Content Brief]

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