Plastin-2

Definition:

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

References:

[1]. Joe Rainger, et al. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. 2017 Aug;38(8):942-946. [Content Brief]

[2]. Guido H Wabnitz, et al. Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. Eur J Immunol. 2007 Mar;37(3):649-62. [Content Brief]

[3]. Bassam Janji, et al. Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells. J Cell Sci. 2006 May 1;119(Pt 9):1947-60. [Content Brief]

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