Potassium channel subfamily K member 4

Definition:

Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

References:

[1]. Stephen G Brohawn, et al. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature. 2014 Dec 4;516(7529):126-30. [Content Brief]

[2]. Stephen G Brohawn, et al. Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science. 2012 Jan 27;335(6067):436-41. [Content Brief]

[3]. Christiane K Bauer, et al. Mutations in KCNK4 that Affect Gating Cause a Recognizable Neurodevelopmental Syndrome. Am J Hum Genet. 2018 Oct 4;103(4):621-630. [Content Brief]

[4]. Marco Lolicato, et al. Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. Neuron. 2014 Dec 17;84(6):1198-212. [Content Brief]

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