Potassium voltage-gated channel subfamily G member 3

Definition:

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1.

References:

[1]. Yorikata Sano, et al. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. FEBS Lett. 2002 Feb 13;512(1-3):230-4. [Content Brief]

[2]. Michael Mederos Y Schnitzler, et al. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704. [Content Brief]

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