Probable ATP-dependent RNA helicase DDX28

Definition:

Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity.

References:

[1]. Hana Antonicka, et al. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Cell Rep. 2015 Feb 17;10(6):920-932. [Content Brief]

[2]. Ya-Ting Tu, et al. The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly. Cell Rep. 2015 Feb 17;10(6):854-864. [Content Brief]

[3]. R Valgardsdottir, et al. Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. J Biol Chem. 2001 Aug 24;276(34):32056-63. [Content Brief]

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