Procollagen galactosyltransferase 1

Definition:

Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV.

References:

[1]. Satoko Miyatake, et al. Biallelic COLGALT1 variants are associated with cerebral small vessel disease. Ann Neurol. 2018 Dec;84(6):843-853. [Content Brief]

[2]. Belinda Schegg, et al. Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases. Mol Cell Biol. 2009 Feb;29(4):943-52. [Content Brief]

[3]. Stephan Baumann, et al. Collagen Accumulation in Osteosarcoma Cells lacking GLT25D1 Collagen Galactosyltransferase. J Biol Chem. 2016 Aug 26;291(35):18514-24. [Content Brief]

[4]. Claire Perrin-Tricaud, et al. Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1. PLoS One. 2011;6(12):e29390. [Content Brief]

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