Prostate tumor-overexpressed gene 1 protein

Definition:

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.

References:

[1]. Hye-Kyung Lee, et al. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J. 2007 Aug 8;26(15):3545-57. [Content Brief]

[2]. Anna Santamaría, et al. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol. 2005 Mar;25(5):1900-11. [Content Brief]

[3]. Anna Santamaría, et al. PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol. 2003 Mar;162(3):897-905. [Content Brief]

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