Proteasome maturation protein

Definition:

Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.

References:

[1]. Yuko Hirano, et al. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature. 2005 Oct 27;437(7063):1381-5. [Content Brief]

[2]. Benjamin Fricke, et al. The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007 Dec;8(12):1170-5. [Content Brief]

[3]. Sylvia Heink, et al. IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9241-6. [Content Brief]

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