Protein Largen

Definition:

Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration.

References:

[1]. Kazuo Yamamoto, et al. Largen: a molecular regulator of mammalian cell size control. Mol Cell. 2014 Mar 20;53(6):904-15. [Content Brief]

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