Protein mago nashi homolog 2

Definition:

Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway.

References:

[1]. Xiaofeng Zhang, et al. An Atomic Structure of the Human Spliceosome. Cell. 2017 May 18;169(5):918-929.e14. [Content Brief]

[2]. Xiechao Zhan, et al. Structure of a human catalytic step I spliceosome. Science. 2018 Feb 2;359(6375):537-545. [Content Brief]

[3]. Kusum K Singh, et al. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. RNA Biol. 2013 Aug;10(8):1291-8. [Content Brief]

[4]. Sebastian M Fica, et al. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 Feb 15;363(6428):710-714. [Content Brief]

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