Protein MCM10 homolog

Definition:

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38.

References:

[1]. Eric M Warren, et al. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009 Sep 4;284(36):24662-72. [Content Brief]

[2]. Emily M Mace, et al. Human NK cell deficiency as a result of biallelic mutations in MCM10. J Clin Invest. 2020 Oct 1;130(10):5272-5286. [Content Brief]

[3]. Benoit Miotto, et al. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep. 2014 Apr 24;7(2):575-587. [Content Brief]

[4]. Masako Izumi, et al. Localization of human Mcm10 is spatially and temporally regulated during the S phase. J Biol Chem. 2004 Jul 30;279(31):32569-77. [Content Brief]

[5]. Sharbani Chattopadhyay, et al. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. Mol Biol Cell. 2007 Oct;18(10):4085-95. [Content Brief]

[6]. M Izumi, et al. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Nucleic Acids Res. 2000 Dec 1;28(23):4769-77. [Content Brief]

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